IMMUNOLOGY2026™ Conference Recordings For Attendees-Tissue-Resident Memory B cells Mediate Local and Metastatic anti-Cancer Immunity

Tissue-Resident Memory B cells Mediate Local and Metastatic anti-Cancer Immunity

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Video Summary

The speaker described research on tissue-resident memory B cells (BRMs), a B-cell population that stays in tissues rather than recirculating in blood and can respond rapidly to repeated challenges. While BRMs have been linked to protection against infections, their role in cancer was unclear. The team found CD69+ BRMs enriched in human tumor tissues and identified a BRM gene signature associated with better survival in some cancers, including head and neck, breast, and skin cancers. In mouse models, they used localized vaccination to generate antigen-specific BRMs in skin and lung, then challenged with tumors. Mice with matching BRMs showed stronger tumor control, while B-cell depletion reduced this protection. Lung BRMs also reduced metastatic burden. Evidence suggested BRM protection may involve antibodies, especially IgA. Overall, the study indicates BRMs can enhance local anti-cancer immunity in primary and metastatic tumors.

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Date April 17, 2026 1:30 PM - 1:45 PM

Room 104AB

Session Targeting Adaptive Immune Responses against Cancer and Other Pathologies

Speaker Abrar Samiea

Track Vaccines and Immunotherapy (VAC)

Year 2026

Keywords

tissue-resident memory B cells

BRMs

tumor immunity

cancer survival

IgA antibodies

April 17, 2026 1:30 PM - 1:45 PM

104AB

Targeting Adaptive Immune Responses against Cancer and Other Pathologies

Abrar Samiea

Vaccines and Immunotherapy (VAC)

2026