IMMUNOLOGY2026™ Conference Recordings For Attendees-Tmem119+ microglia controls blood-brain barrier disruption through MHC class I restricted antigen presentation in a CNS vascular disease model

Tmem119+ microglia controls blood-brain barrier disruption through MHC class I restricted antigen presentation in a CNS vascular disease model

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Video Summary

Marina presented research on how microglia antigen presentation through MHC class I, especially H2-Db, influences CD8 T-cell responses in the brain during TMEV infection. Using a microglia-specific conditional knockout, she showed that deleting H2-Db did not change total CD8 T-cell numbers, but reduced perforin expression in CD8 and virus-specific CD8 cells. In a severe CNS vascular disease model, this deletion lowered CD8 infiltration and blood-brain barrier disruption. Parabiosis showed the effect was local to the brain, not driven by peripheral factors. Overall, microglial H2-Db promotes full CD8 effector function and BBB damage.

Meta Tag

Date April 18, 2026 9:57 AM - 10:09 AM

Room 104AB

Session Immunity at CNS Barriers and Borders

Speaker Marina Seady

Track Neuroimmunology (NEUR)

Year 2026

Keywords

microglia antigen presentation

MHC class I H2-Db

CD8 T-cell effector function

blood-brain barrier disruption

TMEV infection

April 18, 2026 9:57 AM - 10:09 AM

104AB

Immunity at CNS Barriers and Borders

Marina Seady

Neuroimmunology (NEUR)

2026