IMMUNOLOGY2026™ Conference Recordings For Attendees-Translational control of T cell expansion and autoimmune responses by a non-conventional RNA binding protein

Translational control of T cell expansion and autoimmune responses by a non-conventional RNA binding protein

Video Transcription

Video Summary

Shachi Vyas described research on ARID5A, an RNA-binding protein induced during CD4 T-cell activation. While ARID5A is known to stabilize inflammatory mRNAs, her lab found it also promotes mRNA translation. ARID5A knockout T cells showed reduced protein synthesis and impaired proliferation, but normal activation markers, signaling, and apoptosis. Ribosome profiling revealed decreased translation of ribosomal and initiation-factor mRNAs. Polysome profiling and co-immunoprecipitation suggested ARID5A associates with EIF4G and the 40S ribosomal subunit to support translation initiation. The work links ARID5A to T-cell expansion and may inform therapies for autoimmune inflammation.

Meta Tag

Date April 16, 2026 10:30 AM - 10:45 AM

Room 153AB

Session Epigenetics and Post-Transcriptional Regulation

Speaker Shachi Vyas

Track Immune Response Regulation: Molecular Mechanisms (IRM)

Year 2026

Keywords

ARID5A

CD4 T-cell activation

mRNA translation

translation initiation

autoimmune inflammation

April 16, 2026 10:30 AM - 10:45 AM

153AB

Epigenetics and Post-Transcriptional Regulation

Shachi Vyas

Immune Response Regulation: Molecular Mechanisms (IRM)

2026