IMMUNOLOGY2026™ Conference Recordings For Attendees-UVB Phototherapy Induces a Stress-Driven Anergy Pathway as a Novel Axis of T Cell Regulation

UVB Phototherapy Induces a Stress-Driven Anergy Pathway as a Novel Axis of T Cell Regulation

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Video Summary

The speaker described how UVB phototherapy modulates T-cell immunity in skin disease. Using mouse single-cell analyses and human vitiligo samples, the study found two main systemic effects: expansion of activated regulatory T cells driven by inflammatory cytokines, and induction of CD4 T-cell anergy caused by missing co-stimulation. UVB also reduced pathogenic gamma-delta T cells in skin-draining lymph nodes. In humans, phototherapy shifted T-cell profiles toward healthier patterns and reduced memory T-cell populations. Overall, chronic inflammatory cytokine exposure appears to paradoxically suppress T-cell responses, making UVB a unique immunosuppressive treatment.

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Date April 16, 2026 2:00 PM - 2:15 PM

Room 253

Session Therapeutic Modulation of T Cells for Autoimmune Diseases

Speaker Avishai maliah

Track Therapeutic Approaches to Autoimmunity (THER)

Year 2026

Keywords

UVB phototherapy

T-cell immunity

regulatory T cells

vitiligo

immunosuppression

April 16, 2026 2:00 PM - 2:15 PM

253

Therapeutic Modulation of T Cells for Autoimmune Diseases

Avishai maliah

Therapeutic Approaches to Autoimmunity (THER)

2026