IMMUNOLOGY2026™ Conference Recordings For Attendees-Unmasking the in vivo role of IGF1R in Chronic lymphocytic leukemia and identifying novel inhibitors for its function

Unmasking the in vivo role of IGF1R in Chronic lymphocytic leukemia and identifying novel inhibitors for its function

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Video Summary

The speaker presents research on chronic lymphocytic leukemia (CLL), a common adult B-cell cancer, and focuses on insulin-like growth factor receptor 1 (IGF-1R) as a survival pathway that CLL cells may use when B-cell receptor signaling is blocked. Using a mouse model that deletes IGF-1R in B cells and crosses it with a TCL1 CLL model, the team found reduced spleen enlargement and fewer leukemia cells, showing IGF-1R supports CLL development in vivo.  <br /><br />They then screened human peptide libraries for molecules that block IGF-1R and identified an IGF-binding protein 6 fragment (IGF-BP6 LCT) that directly binds IGF-1R and prevents IGF-1 from activating it. In patient samples, this fragment was higher in indolent mutated CLL and lower in aggressive CLL, suggesting clinical relevance. The team plans further mechanistic modeling and peptide-based therapeutic design.

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Date April 18, 2026 10:15 AM - 10:30 AM

Room 102

Session Animal Models and Multi-omics Technology

Speaker Moumita Datta

Track Immune Mechanisms of Human Disease (HUM)

Year 2026

Keywords

chronic lymphocytic leukemia

IGF-1R

B-cell receptor signaling

IGF-BP6 LCT

peptide therapy

April 18, 2026 10:15 AM - 10:30 AM

102

Animal Models and Multi-omics Technology

Moumita Datta

Immune Mechanisms of Human Disease (HUM)

2026