IMMUNOLOGY2026™ Conference Recordings For Attendees-Vessel-Associated Microglia Maintain Vascular Integrity and Prevent Early Hemorrhage in Brain Tumors

Vessel-Associated Microglia Maintain Vascular Integrity and Prevent Early Hemorrhage in Brain Tumors

Video Transcription

Video Summary

The speaker studies glioblastoma, a highly aggressive brain tumor rich in myeloid immune cells. Using lineage tracing and imaging, they found that microglia and macrophages occupy distinct tumor niches: microglia dominate the peritumor region, especially around blood vessels, while macrophages are more common in the tumor core. These vessel-associated microglia become more abundant and stable near tumors. When microglia were depleted with CSF1R inhibitors, mice died earlier from sudden paralysis and brain hemorrhage, even when tumors were not larger. The findings suggest vessel-associated microglia help protect tumor vasculature, and their loss may increase hemorrhage risk in CSF1R-targeted therapies.

Meta Tag

Date April 18, 2026 10:33 AM - 10:45 AM

Room 104AB

Session Immunity at CNS Barriers and Borders

Speaker Jiaying Zheng

Track Neuroimmunology (NEUR)

Year 2026

Keywords

glioblastoma

microglia

macrophages

tumor vasculature

CSF1R inhibitors

April 18, 2026 10:33 AM - 10:45 AM

104AB

Immunity at CNS Barriers and Borders

Jiaying Zheng

Neuroimmunology (NEUR)

2026