IMMUNOLOGY2026™ Conference Recordings For Attendees-Wild-Derived Microbiota Protect Against Diet-Induced Obesity via an Immune-Mediated Effect on Brown Adipocytes

Wild-Derived Microbiota Protect Against Diet-Induced Obesity via an Immune-Mediated Effect on Brown Adipocytes

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Video Summary

Researchers studied “wilding” mice, which carry a diverse wild-like microbiome and are resistant to diet-induced obesity. They found this protection is stable across sex, age, and genetic background, and is linked to higher energy expenditure driven by brown adipose tissue. Wilding mice showed a distinct brown fat transcriptome and increased thermogenic pathways. The effect depends on early-life exposure to the microbiome and requires CCR2-positive immune cells, especially monocytes, but not IL-33 or STAT6 type 2 immunity. Transferring wild-type bone marrow restored obesity resistance in CCR2-knockout wilding mice, suggesting microbiome-shaped immune cells regulate brown fat and metabolism.

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Date April 18, 2026 1:09 PM - 1:21 PM

Room 153AB

Session Pathophysiology of Cytokines and Chemokines

Speaker Shahar Azar

Track Cytokines and Chemokines and their Receptors (CCR)

Year 2026

Keywords

wilding mice

microbiome

brown adipose tissue

obesity resistance

CCR2-positive immune cells

April 18, 2026 1:09 PM - 1:21 PM

153AB

Pathophysiology of Cytokines and Chemokines

Shahar Azar

Cytokines and Chemokines and their Receptors (CCR)

2026