IMMUNOLOGY2026™ Conference Recordings For Attendees-immgenT CD8 framework unifies mouse CD8+ T cell states across immunity

immgenT CD8 framework unifies mouse CD8+ T cell states across immunity

Video Transcription

Video Summary

Giovanni describes an ImGen-T CD8 reference atlas built from ~200,000 cells and 21 stable clusters, used to unify CD8 T cell states across infections, tissues, aging, tumors, and chronic infection. Using markers like CD62L, CD44, CD11C, and KLRG1, the atlas captures effector, memory, tissue-resident, exhausted, and progenitor-exhausted states. A key finding is that the same molecular states recur in very different biological contexts, making traditional names like “memory” or “TRM” less precise. Tissue-resident cells converge on a core CD8Q state, while tissue-specific protein markers still reflect organ heterogeneity. In chronic settings, CD8Q, R, and S form an exhaustion continuum. Progenitor-exhausted cells map mainly to cluster C. Overall, the atlas serves as a “thesaurus” to harmonize CD8 annotations and better interpret immune states across conditions.

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Date April 16, 2026 4:00 PM - 5:30 PM

Room 151

Session Resource Highlight: immgenT: A Community Reference Atlas for Mouse T Cells

Speaker Giovanni Galletti

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

CD8 T cell atlas

ImGen-T

exhaustion continuum

tissue-resident CD8Q

progenitor-exhausted cells

April 16, 2026 4:00 PM - 5:30 PM

151

Resource Highlight: immgenT: A Community Reference Atlas for Mouse T Cells

Giovanni Galletti

Computational and Systems Immunology (COMP)

2026