IMMUNOLOGY2026™ Conference Recordings For Attendees-immgenT Treg: a reference landscape of regulatory T cell states in mice

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Video Summary

The speaker, Antoine, presented work from the ImmuNet T dataset showing that regulatory T cells (Tregs) are more heterogeneous than previously thought. He described how they were subclustered into six main populations (A–F), plus proliferative and minor subsets, each defined by distinctive markers and flow cytometry gating strategies. The team validated these signatures with CITE-seq and flow cytometry across multiple tissues. They found that tissues contain mixtures of Treg clusters rather than one unique subset, with some tissue bias and mild transcriptomic fine-tuning. During immune perturbation, however, Treg composition was dramatically reshuffled, though cluster-specific gene programs were still largely conserved. A key finding was a vascular trafficking TregF population marked by CD49B and CD29, especially enriched in placenta, blood, liver, and other vascularized tissues. Overall, the work proposes a unified framework for Treg diversity and raises questions about spatial localization, antigen experience, and plasticity.

Meta Tag

Date April 16, 2026 4:15 PM - 4:30 PM

Room 151

Session Resource Highlight: immgenT: A Community Reference Atlas for Mouse T Cells

Speaker Antoine Freuchet

Track Computational and Systems Immunology (COMP)

Year 2026

Keywords

regulatory T cells

Treg heterogeneity

ImmuNet T dataset

CITE-seq and flow cytometry

vascular trafficking TregF

April 16, 2026 4:15 PM - 4:30 PM

151

Resource Highlight: immgenT: A Community Reference Atlas for Mouse T Cells

Antoine Freuchet

Computational and Systems Immunology (COMP)

2026