OasisLMS

Tuft cells

Unique nasal cell states induced by common respiratory viruses

How to Have a Successful Postdoctoral Experience

Fate mapping with Cd3giCre reveals a subset of ILC2s prevalent in pre- and neonatal stages

President's Address: Immunology in Space and Time

Immune Cell and Stromal Cell Interactions

Understanding the Immunobiology of Severe and Life-Threatening Influenza Infection in Children

Thetis cell regulation of intestinal tolerance

Immunology and Infection Biology in Cinema: An Interdisciplinary Undergraduate Course

Recruitment of immune cells from vascular and avascular sites to altered tissues

Oncostatin M Limits Lung Injury during Influenza by Modulating Leukocyte Recruitment and Inducing Tissue Repair Factors

New Models for Studying Cell:Cell Interactions

Immune profiling uncovers correlates of severity in multisystem inflammatory syndrome in children

A seeding reaction to commensal microbes in human newborns

Beyond Memorization: Active and Adult Learning Strategies in Undergraduate Immunology

Integrin agonists: new tools for organoids

The impact of skin-like CD103+ ILC2s on lung immunity

Innate-like Lymphocyte Responses and Memory

Engineering CAR T Cells for Emerging Targets in Cancer

Maternal regulation of offspring immunity

Computer-Based Models to Teach Immunology from the Undergraduate to Professional and Graduate Level

Local immune networks promote respiratory IgA responses after mucosal vaccination

CAR-T Cell Therapy for Autoimmunity I

Maternal-offspring immune partnerships

Comparative immunodermatology approaches for skin diseases in pet dogs and people

AAI-Recommended Immunology Content Learning Objectives for Undergraduate Medical Education in the U.S.A.

Stem-like and effector peripheral helper T cells orchestrate distinct local immune responses in rheumatoid arthritis

CAR-T Cell Therapy for Autoimmunity II

Role of Periodontitis in Inflammatory Bowel Disease

Never working a day in your life: Turning your passions into a career

Immunology Integration and Team-Based Learning (TBL) Enhance Comprehension in a Foundations to Medicine Module

AI and decoding the TCR repertoire

Antigen-independent formation of renal Trm-like CD8 T cells perpetuates hypertension

GPS integration of electronic health record and GWAS data to predict autoimmune disease progression risk

Pseudomonas instigates neutrophil accumulation in adipose tissue and insulin resistance in obesity

Studying humoral immune learning by exploring and exploiting analogies to how machines learn

Monocyte-Derived ADA2 Regulates Myeloid-T Cell Crosstalk and Drives Pro-Inflammatory Responses Linked with Intestinal Inflammation in Crohn's Disease

Machine learning to advance rheumatoid arthritis treatment strategies

The Vaccine Integrity Project: why evidence matters…now more than ever

Immune resilience after pediatric cancer treatment

Immune Safety in Pharmaceutical Development: Navigating Complexities and Embracing New Approach Methodologies

Probing the function of human immune lectins

Conversations that Connect: Helping the Public Understand, Trust, and Engage with Science, Sponsored by the AAI Public Communications Comm.

CCR4 is required for negative selection and suppression of Treg development by modulating interactions with and functions of thymic APCs

Road to Qualification: Insights from NIH's Complement‑ARIE Program and the FNIH‑Coordinated Validation and Qualification Network

Tumor-infiltrating microbes and their impact on the tumor immune microenvironment

Optimizing structural biology for improved human antibody effectiveness: pharmacology and mathematical modeling to achieve better clinical outcomes; from autoimmunity to cancer

Hematopoietic origins of an early wave of CD8+ T cells

Crosstalk of the environment and the immune system - challenges and opportunities, Sponsored by the German Soc. For Immunol. (DGfl)

Micro-communities of microbes that modulate immune responses

A human tonsil organoid platform to model TLR-driven B cell differentiation and heterogeneity in SLE

Novel Mouse Models Allow Selective Labelling and Depletion of Perinatal and Adult-derived Regulatory T Cells

Crosstalk of the environment and the immune system - challenges and opportunities, Sponsored by the German Soc. For Immunol. (DGfl)-2

Reversible ISG15 conjugation regulates antiviral innate immunity and intracellular metabolism

Methionine metabolism shapes epigenetic and functional programs of developing CD8+ T cells

Innate immune responses to mirror molecules

Epigenetic and lineage-specific transcription factors regulate the cell type specific induction of type I and type III interferons

Molecular mechanisms controlling the growth and functional characteristics of the neonatal and juvenile thymus microenvironments

Mirror-image biomolecules: properties, applications, and why chirality matters

Early chromatin and transcriptional changes driven by NFAT and its transcriptional partners in 'exhausted' CD8+ T cells

Derivation of Mesenchymal Stem Cells from Induced Pluripotent Stem Cells and Their Application in Genetic Disease Modeling

Adaptive immune responses to mirror antigens

Sterile inflammation is a key feature of intrinsic tissue ageing

DUSP4 regulates anti-tumor CD8+ T cell response in colorectal cancer

Beyond the immune system: countermeasures for mirror life

Environmental dysregulation of MAIT cells in obesity

CD4+ T cell-mediated Immune Surveillance during Intestinal Tumor Initiation

The nucleoside transporter SLC29a3 supports phagosomal TLR signaling and TRPML1 activity in dendritic cells

Mechanisms that support obesity-associated inflammation in human prediabetes

Spatial colocalization of neoantigen-expressing tumor cells and cognate T cells in cancer

The bicarbonate transporter SLC4A2 orchestrates T cell development and function

Studying fat as a driver of inflammatory disease

Glucocorticoid signaling shapes the differentiation of tumor-infiltrating CD8+ T cells through TXNIP-dependent metabolic rewiring

Mitochondrial Calcium Signaling in Age-associated Inflammation

What you eat-and how much-shapes anti-tumor immunity

Characterizing Host-Viral Interaction Interfaces for Insights into Viral Transmission and Infections

Tuning Innate Immune Signaling Through Ion Channels: Regulation of cGAMP-STING by Puromycin-Sensitive Aminopeptidase

Postbiotics alter immunometabolism during metabolic disease

A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation

Leveraging immgenT to understand impacts of diverse microbial exposure on circulating CD8+ T cells

The enteric nervous system shields colon cancer from immunosurveillance

Systems Immunology of Long Covid: Insights from the STOP-PASC Clinical Trial

immgenT Treg: a reference landscape of regulatory T cell states in mice

Tumor-innervating nociceptors drive immuno-suppressive monocyte differentiation to prevent T cell-mediated anti-cancer immunity

Strain-specific variation drives CD8+ T cell activation responses

immgenT CD8 framework unifies mouse CD8+ T cell states across immunity

From the lab to FDA-approval: clinical translation of the inflammatory reflex

High-Throughput Proteomic Profiling of Hepatocyte Response to Oncologic Compounds for Toxicity and Immune Risk Prediction in Drug Development

immgenT-GP: understanding T cells through gene programs

Dietary Iron Overload Rewires Regulatory T Cells into IL-17-Mediated Proinflammatory Effectors Aggravating Yersinia enterocolitica Infection

CD1-Mediated Lipid Antigen Presentation Orchestrates Neuroinflammation in Alzheimer's Disease

immgenT Resources: Flow panels, analysis tools, and website to use immgenT in your research

At the crossroads of IL-17 signaling: IL-17 signal transduction in autoimmunity and fungal infections

Liver metastasis limits immunotherapy efficacy by dismantling systemic anti-tumor T cell responses through unconventional antigen presentation

Introduction to the immgenT Project

Introduction: 20 Years of Th17 Cells: Discovery and Clinical Impact

A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomach.

B cells as effectors in tissue

Unexpected roles of interleukin‑17 and identification of its target cells

Structural basis of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity

Antigen presenting B cells direct TfH localization during M. tuberculosis infection

The immune cellular network defined by RORyt

Regulatory T Cells Act as Tolerogenic Antigen Presenting Cells to Suppress Autoimmunity

Role of IL-27-producing B cells in the antibody response and anti-viral immunity

A unique subset of allergen specific T helper 2+17 tissue resident memory cells is established in a mouse model of allergic inflammation

Sex differences in hematopoietic progenitors: defining the roles of gonadal vs chromosomal sex

Major Symposium F: 20 Years of Th17 Cells: Discovery and Clinical Impact

Loss of STAT1 and Nitric Oxide Signaling Compromises the Development of the Stress Erythropoiesis Niche

Transcriptional programs controlling natural killer cell effector maturation and function

Sympathetic nerves regulate T cell differentiation in viral infection and cancer

Single-cell mapping of stress-conditioned hematopoiesis reveals distinct molecular adaptation separating resilience from susceptibility

Innate lymphocyte regulation of physiology & tolerance in the intestine

Peripheral immune signatures that orchestrate complex behavior

Interrelationship of Peritoneal Fluid and Mesothelial Macrophages and Species-Specific Pathways in Their Maintenance and Repopulation

Elucidation of human natural killer cell development

Spatial and metabolic guidance on tailoring anti-tumor immunity

Inflammatory hematopoiesis drives intestinal inflammation and is modulated by anti-TNF therapy

Dynamic regulation of NR1B1 and its impact on the differentiation of effector cytotoxic T cells

A sinus-proximal fibroblast niche supports B lymphopoiesis in the developing dura mater

Transcriptional control of type I dendritic cell development via Irf8 superenhancer

Skull bone marrow is an early source of antiviral CD8 T cell priming and expansion during neurotropic virus infection

Epigenetic noise for immune tolerance

Immune Cell Derived 1,25(OH)2D3: A Critical Defense Against Influenza Infection

Generation of early memory CD8+ T cells in humans: markers and mechanisms

HSV-2 Infection Induces Lasting Transcriptional and Functional Changes in Vaginal Tissue NK Cells

Decoding Immune Responses in Heart Transplantation: Lessons for Xenografts and Clinical Translation

Antigen-specific CD8 T cells are primed in the bone marrow by migratory myeloid DCs bringing antigen from the brain following inflammatory injuries

Multiomic profiling in Longitudinal Transplantation studies for Innate and Adaptive Immunity Insights

Regulatory maturation of cDC1 accelerates effector CD8 T cell contraction after severe influenza A virus infection.

Signaling dynamics in cytokine-driven gene control

A Tonsil Organoid Model for Epstein-Barr Virus-Host Immune Interactions in Germinal Centers

Transformational efficacy for type 2 cytokine-driven disease with multi-functional antibody therapeutics

Revealing NMOSD Molecular Mechanisms in an AQP4-Induced Animal Model

Molecular and cellular regulation of inflammation

Activation, localization, and autoantibody production of tissue-based age-associated B cells in human type 1 diabetes

Inflammasome pathway inhibition in autoinflammatory diseases

A Critical Role for NKG2D Signaling in beta cell-specific CTL Generation and NOD Diabetes

T-cell Signaling and Engineering

Diabetogenic CD8 Tcells are highly adaptive in beta-cell antigen recognition

Mechanical softness: paving the road of CAR T therapy

The role of T cells in uterine turnover and homeostasis

Lactate modulation of macrophage function in inflammation and resolution

Self-reactive CD4+ T cells display diverse differentiation in health and gain stem-like features in rheumatoid arthritis

Interdisciplinary design of NK-based immunotherapies

Translational control of T cell expansion and autoimmune responses by a non-conventional RNA binding protein

Autoimmune Dysfunction in FTD-ALS Spectrum Disease

Copper Shapes T Cell Metabolism and Epigenetics to Drive Pathogenic Th17 Cell Function in Autoimmunity

Age Dependent Immune Remodeling as a Driver of Autoimmune Disease

KDM5C-regulated anabolic metabolism is required for T cell expansion

Is Alzheimer's Disease an Autoimmune Disorder of Innate Immunity

A distal transcribed enhancer of KRAS fine-tunes Tfh-mediated vaccine response

Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease

Exportin-5 Links miRNA Biogenesis to the Preservation of B Cell Receptor Surface Expression

Harnessing Neuroimmune Interactions for Disease Modification in Alzheimer's & Parkinson's

Targeting convergent pathways prevents the differentiation of tissue-resident memory T cells from multilineage progenitors in the arthritic synovium

Complement and immunosuppressive tumour microenvironments

Antigen dependency defines memory and exhausted CD8 T cell fates

Complement as Driver of Age-dependent Progression: Insights from Multiple Sclerosis and a Mouse Model

The Ikaros zinc finger transcription factor Aiolos promotes the formation of lung-resident memory CD8+ T cells.

CBM-opathies: New insights on lymphocyte metabolism and effector function

Dissecting transcription factor networks for tissue-resident CD8 T cell differentiation and maintenance

A novel inborn error of immunity perturbs linear ubiquitin homeostasis and causes pyoderma gangrenosum

Nrf2 suppresses inflammatory Th1/Th17 responses and promotes regulatory T cell differentiation by CD4⁺ T cells to alleviate ulcerative colitis

HIPC Coordinating Center

GC-independent B cells contribute to durable humoral responses and protection in mice

Placental Immune Cell Dynamics in Healthy and Complicated Pregnancies: Insights from 1.2 Million Maternal and Fetal Cells

Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution

Host Genetics and B Cell Reprogramming by Epstein-Barr Virus

Skeletal muscle as an active immune niche orchestrating adaptive responses to replicon RNA vaccination

CD4 T cell memory in acute and chronic viral infection

Airway B cells regulate neutrophilic inflammation via Fas:FasL pathways during respiratory Mycoplasma infection

Mammary tumour hijacking of myelopoiesis

Neutrophil Extracellular Traps Prime B Cell-Mediated Fibrogenesis in MASH by Silencing HES1 and Promoting Plasma Cell Differentiation

Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes

Regulatory B cells ameliorate experimental periodontitis through promoting macrophage-mediated pro-resolving functions

Leveraging extrafollicular B cells for the treatment of solid tumors

Opposing Effects of Metoclopramide and Bromocriptine on Melanoma Response to Immune Checkpoint Blockade

Learning B and T cell immunology from novel vaccine efforts

Skin mites enhance virtual memory T cell responses against immune checkpoint inhibitor-resistant tumors

Myoglobin expression boosts T-cell metabolism and antitumor effector function

Targeting glycans for cancer immunotherapy

Beyond Memorization: Active and Adult Learning Strategies in Undergraduate Immunology

Contemplating immunology: using contemplative pedagogy practices to build critical thinking skills and confidence in data analysis and interpretation.

Bridging the Gap in Flow Cytometry Training: A Practical Workflow for Teaching Autofluorescence Management in Immunology

Powering health literacy with STEAM: Using an infographic project to teach the public about complex topics in immunology

T Cell-Specific Deletion of Glutaminase (Gls1) Lowers AutoAb Production in Lupus Mice by Altering Metabolism and Function of Follicular Helper T Cells

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation

De novo pyrimidine synthesis controls lupus-prone germinal center B cell and plasma cell fates

Itaconate alleviates autoimmune uveitis by boosting FOXP3 and blocking succinate-driven inflammation

Siglec-F+ neutrophils are pro-inflammatory and exacerbate C. difficile colitis

CX3CR1+ myeloid cell-intrinsic NOD2 signaling limits Crohn's disease-associated intestinal fibrosis

Noncanonical role for Caspase-5 in the human intestinal epithelium

MAIT17 Cells and IL-17-Driven iBALT Formation Protect Against Pulmonary Tularemia

SPIC-dependent erythrophagocytic macrophages promote bacterial tissue persistence during Salmonella infection

Myeloid-specific NLRP12 is a checkpoint of colonic inflammation by promoting taurine-driven microbiota

Imaging Flow Cytometry Enhances Characterization of Immune Cell Phenotype and Function

Modular Evaluation of Multi-Platform Human In vitro Systems (MEMPHIS): A Methodological Advancement in Vaccinology

Rapid Assembly of Oligo Pools into Medium-Scale T Cell Receptor Lentiviral Libraries

Linking zygosity and allelic balance to phenotype with programmable heterozygous editing and allele-specific single-cell RNA sequencing

Rapid expansion and comprehensive profiling of lung tumor infiltrating lymphocytes using a highly scalable TCR sequencing method

GLUT1 in Memory CD4+ T-cells Correlates with Sustained Antibody Responses and Polyfunctionality Post-RSV Vaccination in Immunocompromised Individuals

Processing-Optimized Multi-Epitope mRNA Vaccine Enhances HIV-1-Specific CD8⁺ T Cells

Toward a Pan-Arenavirus T-cell Vaccine: Identification and Preclinical Evaluation of Conserved Epitope constructs

Development of T-cell-based immunotherapy against chronic Hepatitis B infection

Bivalent vaccination fails to enhance conserved spike T cell responses across BetaCoronaviruses

Impaired B Cell and cTfh Immune Pathways Underlie Influenza Vaccine Hyporesponsiveness in Older, Frail, and Multimorbid Adults

Differential effect of Recombinant Zoster Vaccine (RZV) and Zoster Vaccine Live (ZVL) in a controlled human infection model (CHIM) of VZV reactivation

Host-Parasite Interactions of Intraerythrocytic Malaria Infections

An Immunological Wildfire: Trichomonas vaginalis sparks pyroptosis in ectocervical cells

Clostridioides difficile-Driven Expansion of IL1B+ Monocytes Amplifies Neutrophil Recruitment in Ulcerative Colitis

Effects of type 2 diabetes mellitus on fibrosis formation in post-tuberculosis lung disease

Characterizing the Alveolar Macrophage and Neutrophil Responses to Inhaled Coccidioides Spores using Ce3D-cleared Precision-Cut Lung Slices

KLF2 regulates CD8 T cell differentiation and migration in infection and cancer

RORα governs CD8⁺ T cell memory subset specification and offers a therapeutic node for antiviral immunity

A BACH2-STAT5 transcriptional module licenses a short intracellular C3 proteoform in activated CD4+ T cells

RNF144A enforces IL-2-STAT5 dominance over RAF-ERK-MAPK signaling in antiviral CD8 T cells

Heterogeneity in the Naïve CD8⁺ T Pool Shapes the Infection Response

Decoding Histone-DNA Methylation Crosstalk in Exhausted T Cells to Enhance Immunotherapy

Prime-Target neoantigen vaccination strategy enhances neoantigen-specific T cell immunity at the tumor microenvironment in murine cold tumor models

Antibody-Drug Conjugates (ADCs) as Adaptors for Universal CAR T cells

Intratumoral administration of a single dose of the HEPLISAV-B Vaccine and IL-15 complexes induces tumor regression in Triple Negative Brest Cancer

In situ Transglutaminase 2-mediated Crosslinking of Engineered IL-7 to the Tumor Matrix Enhances Immunotherapy and Anti-PD-1 Response

mRNA Vaccines Enhance Tumor Control and Synergize with 4-1BB Costimulatory Therapy

Microbiome-Derived RNA as a Trigger for Heritable Innate Immunity

A Novel Mediator Extracellular Caspase-1 Worsens Acute Lung Injury in Sepsis

Investigating the role of Dectin-1 in the host immune responses to Schistosoma mansoni cercariae in acute schistosomiasis

TRIM21 Orchestrates Inflammasome Assembly and Drives Autoinflammatory Pathology.

Structural and biological bases of cGAS bending bubble DNA to form a hyperactive dimer

HuR-SerpinB9 Axis Regulates Tumor T-Cell Fitness and Persistence via Post-Transcriptional Control

Burn Baby Burn: Leveraging Fatty Acid Oxidation to Improve CD8+ T cell Efficacy Against Ovarian Cancer.

The BMP-KLF3 circuit promotes resilient programming in CD8+ T cells during chronic infection and cancer

CAR-T with ICOS costimulation lacks therapeutic efficacy in patients due to strong trogocytosis and failure of expansion

Spatial IgA Plasma Cell Niches Drive Anti-Tumor Immunity in Pancreatic Cancer

Metabolic checkpoint AhR prevents pathogenic B cell expansion in murine lupus

SP2H selectively depletes Stimulator of Interferon Genes (STING), reducing inflammation and improving survival in Trex1-/- mice

Reduced BCMA Signaling Disrupts the BAFF/APRIL Axis and Promotes Inflammatory Cytokine Production by B Cells in Multiple Sclerosis.

The antigen-specific immunotherapy, AKS-107, selectively depletes anti-insulin B lymphocytes in the pancreas and reduces insulitis in T1D-prone mice

Functional dichotomy of GC-Derived Memory B Cells in Lupus: A Role for FCRL5+ MBCs in ASC Differentiation

GNTI-932: A Targeted, Scalable, and Hypoimmune Allogeneic Engineered Treg therapy for the treatment of Inflammatory Bowel Disease.

Antigen-specific depletion of gluten-reactive T cells for the potential treatment of celiac disease

UVB Phototherapy Induces a Stress-Driven Anergy Pathway as a Novel Axis of T Cell Regulation

Engineered Nanobodies to Direct and Visualize Durable Tolerance

Site-Selective Proximity-Synthetic Editors Rewrite p53 Acetylation to Dynamically Control Treg Lineage Differentiation

First Oral Small-molecule Inhibitors Designed by Generative AI Achieve Biologics-Like Pan-Inhibition of IL-17AA, AF, and FF Dimers

Understanding unconventional T cell development to generate an 'off the shelf' immunotherapy to treat human diseases

Single-cell buoyant mass reveals CD8⁺ T-cell fitness and predicts melanoma checkpoint response

Morning influenza vaccination elicits superior antigen-specific immune responses in adults aged 60-85 years

Optimizing Cancer Antibody Effectiveness: Pharmacology and Mathematical Modeling to Achieve Better Clinical Outcomes

Single Cell Insights on Inflammation-Induced Transitional States in Benign Prostate Hyperplasia

BCG vaccine induces distinct metabolic shifts in monocytes in vitro and peripheral blood plasma in vivo: Implications for neonatal trained immunity

T cell dysfunction during Staphylococcus aureus osteomyelitis in humanized mice

Rv2140c is targeted by follicular helper T cells in M.tuberculosis exposed γ Interferon Release Assay negative populations in Uganda and South Africa

Antibody response to Burkholderia pseudomallei in a 13-year chronic infection: Relationship of antibody response to bacterial genomics and proteomics

Tissue resident memory cells formed after neonatal viral infection contribute to asthma

Iron metabolism In Dendritic Cells is important for Induction of Follicular Helper T Cell Subsets in Allergy

CTLA-4 mediates oral immunotolerance against systemic allergic sensitization to environmental allergens

Allergen-specific regulatory T cells form lung resident memory capable of suppressing Th2 recall responses to allergen

Lung Tfh13 Differentiate from Lymph Node-derived Progenitor Tfh Cells to Sustain Allergic Antibody Responses

Antigen Presentation by Tumor Endothelium Promotes CD8+ T Cell Recruitment

Cancer-associated metabolites stimulate mucosal-associated invariant T cells for cancer cell killing.

Targeting genome organizer Satb1 in regulatory T cells safely and potently enhances cancer immunity

Loss of the Vitamin D Receptor Exacerbates Influenza Severity Through Dysregulated Immunity and Elevated Parathyroid Hormone

Defining viral-host mechanisms of neuroinflammation after human metapneumovirus infection

Protective Role of Interferon Omega in Human Airway Epithelium During Human Metapneumovirus Infection

Inflammatory monocyte recruitment depends on adventitial fibroblast-derived CCL2 following influenza A virus infection

Macrophage metabolic reprogramming facilitates viral entry and pyroptosis

Infection history and cellular origin shape long-term alveolar macrophage reprogramming

PKN1 is a Novel Therapeutic Target for the Optimal Control of GvHD

Evidence for Human Thymopoiesis in a Porcine Thymus Graft and T Cell Tolerance to the Source Pig in a Human Recipient of a Thymokidney Xenotransplant

IL-39/IL-39R Signaling Drives Acute Graft-versus-Host Disease by Promoting Pathogenic T-Cell Responses

Metabolic Regulation of Alloimmunity: Inhibition of PKM2 Attenuates T Cell Activation and Prolongs Allograft Survival

Coordinated circulating and tissue-based T cell responses precede xenograft rejection

Tim-4 Effector B Cells Express a Th17-Like Proinflammatory Cytokine Module That Is Restrained by Nur77

TLR7/9-IFNα-LDHB Checkpoint Rewires NET Subtypes in Lupus

Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development, Sponsored by Breakthrough T1D

Antigen-driven MAIT cell activation restores skin Treg levels and attenuates lupus-like skin inflammation

Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development, Sponsored by Breakthrough T1D-2

IRF1 tunes the IRF4-IRF8 axis to drive effector B-cell fates in autoimmunity and inflammaging

Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development, Sponsored by Breakthrough T1D-3

Role of B cell activation through Toll-like receptors in Systemic Lupus Erythematosus.

Rewriting Autoimmunity: New Immunologic Insights Transforming T1D Therapy Development, Sponsored by Breakthrough T1D-4

GM-CSF-IRF5 Axis as a Therapeutic Target in TLR7-Mediated Macrophage Activation Syndrome

E3 Ubiquitin Ligase Peli1 Regulates TLR7-Driven Spontaneous Germinal Center and Plasma Cell Development

Discovery of potent, selective and insurmountable MRGPRX2 antagonists for mast cell-driven disorders

Targeting the Adenosine-Adenosine Deaminase-1 Axis to Restore HIV-Specific CD8⁺ T Cell Function

Host HLA Allelic Variation Shapes Risk of Severe SARS-CoV-2 Infection and Long COVID

Persistent IL-17 Cytokine Patterns and Th17 Expansion Characterize Chronic Critical Illness after Severe Trauma

Strategy to activate ephrin-Eph signaling pathways and develop a novel therapeutic approach to regenerative wound repair in veterinary medicine

The Evolutionary Diversification of CD300s Reveals How Gene Duplication and Structural Innovation Shift the Landscape of Immune Recognition

Structural integrity of antigen receptors

Organized mucosal associated lymphoid tissue is present in the nurse shark spiral valve

A primordial variable lymphocyte receptor-like gene expressed in T-like lymphocytes of jawless vertebrates

Combination XPO1/PD1 inhibition for canine cutaneous T cell lymphoma: a comparative oncology approach

Integrin-mediated entry and fibroblast-supported retention in memory B cell residency in allergic lungs

Olfactory Receptor 2 Signaling in Monocytes Facilitates Chemotactic Migration to Atherosclerotic Aorta Due to Octanal from Dysfunctional Endothelium

Heat can STING: Defining the relationship between heat and cGAS/STING activation in iTreg and Th1 CD4+ T cells.

Inborn errors of T cell topographic memory underlie organ-selective infectious diseases

CD69 Promotes Rapid Activation of Skin-Resident Memory T Cells

The bacterial quorum-sensing molecule 2′-aminoacetophenone reprograms macrophage metabolism and sustains histone lactylation for persistence.

UVRAG and the VPS34 complex II regulate macropinocytosis via the synthesis of PI(3)P on the plasma membrane

ATF3 Regulates Cholesterol Trafficking in Macrophages

Regulation of Inflammatory Diseases by Solute Carrier Transporters

Homologous MHC Antigens Induce cDC1-like Differentiation from Monocyte-Derived Dendritic Cells

Host Lipid and Mitochondrial Metabolism Networks as Functional Targets for Novel Antimicrobials against Intracellular Bacteria

Developmental and epigenetic remodeling of inflammation in the aging human innate immune system

NLRP3 confers regulatory T cell-mediated control of intestinal inflammation

Lag3-KIEELE domain plays a key role in Lag3-dependent Treg function

Discovery and targeting of human B cell epitopes to counter emerging threats

T cells play a protective role in maintaining spinal health after intervertebral disc injury

Nuclear estrogen receptors modulate regulatory T cell suppressive function

A life with B cells: From activation to antibody responses

Dietary lipids are delivered to Tregs in chylomicrons and determine intestinal Treg survival.

Decidual Natural Killer cells utilize the antimicrobial protein granulysin to control bacterial infection

IL-9 at the Maternal-Fetal Interface Drives a Novel Immunological Mechanism of Preterm Labor and Birth

Persistent uterine inflammation following murine chorioamnionitis predisposes to poor outcomes in subsequent pregnancy

Microbiota-dependent Interferon Lambda Controls Uterine Immunity and Placental Anti-bacterial Responses

TGF-β drives uterine tissue-resident NK cell differentiation crucial for murine pregnancy

Hyperglycemia-induced HIF-1α dysregulation drives epithelial barrier dysfunction and increases susceptibility to oral candidiasis

Absence of the "Don't Eat Me" signal results in aberrant T cell responses to Leishmania major

LOX-1 promotes efferocytosis and oxLDL-mediated immune reprogramming of alveolar macrophages during pneumonia.

Critical role of 4-1BB:4-1BBL axis in humoral immune responses against Plasmodium

Centrosome-associated assembly and trafficking coordinate spatial activation of the NLRP3 inflammasome in primary human monocytes

B7 co-stimulation antagonizes RORγt⁺ regulatory T cells and tolerance to gut microbiota

Multi-omics of controlled microbial naturalization uncovers sex-dimorphic immune maturation

Loss of the microbiota unleashes harmful T cell responses against dietary antigen induced by enteric viruses

Role of Microbial Tryptophan Metabolism in Th17 Activation and Multiple Sclerosis

Epithelial antigen compartmentalization dictates CD4+ T cell fate during C. rodentium infection

Antigen-presenting cell-T cell interactions shaping immune responses to intestinal antigens

Allogeneic Tissue Tregs Improve Disease Outcome in Models of Acute Lung and Kidney Injury

Liver sinusoid constraints make random search of CD8 T cells for Plasmodium parasites efficient

Journey to the undiscovere'd country of B cell memory

Structural Insights and Immunogenic Enhancement of KRAS Neoantigen Recognition by TCRs in Cancer Immunotherapy

A Novel Hybrid Biological-Biomaterial Vector for Antigen Delivery and Human Dendritic Cell Maturation

Tissue-Resident Memory B cells Mediate Local and Metastatic anti-Cancer Immunity

Regulatory T cells turn into multiple pro-inflammatory effector T cells in Mice with Atherosclerosis

Defects in CD8+ T cell suppression by Foxp3-dE2 regulatory T cells

ExTh17 Cells Arising from Th17 Support Chronic RA-Like Inflammation Independent of IL-17

Regulatory T Cell-Derived Amphiregulin Consolidates Transplant Tolerance via EGFR-Mediated T Cell Exhaustion

Loss of TET function in T regulatory cells yields Tfh-like ex-Treg cells with the features of heterochromatin dysfunction.

The role of interferon-stimulated gene IFIT2 in a sex-dependent Treg modulation in CNS autoimmunity

KRAS G12D Blocks Erythroid Differentiation and Promotes Inflammatory Pathways at the Single Cell Level in Myeloid Malignancies

Discovering Shared Mechanisms of Autoimmunity using Omics Technologies

Unmasking the in vivo role of IGF1R in Chronic lymphocytic leukemia and identifying novel inhibitors for its function

Cooperative molecular mimicry drives prolonged autoinflammation in multisystem inflammatory syndrome in children

TIDEPOOL, a method for inferring disease trajectories across cohorts, identifies neutrophil-driven trajectories associated with severity of infections

TyCHE enables time-resolved lineage tracing of B cells in primary and recall germinal center reactions

Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP

ImmPort: An AI Eco-System for Reproducible Immunology Research

Characterizing spatial functional microniches with SpaceTravLR

Sensory neuronal regulation of intestinal inflammation and immunity

Endobiotic glycolipid structure of gut symbionts modulates host inflammatory response

Breast milk-derived signals regulate epithelial cells maturation and gamma delta-IEL colonization to shape early life intestinal homeostasis

Induction of germinal centers in human Peyer's patches shapes robust intestinal adaptive immunity in early life.

A single cell and spatially resolved atlas of the intestinal innate immune response to infection

Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity

Epitope-Specific Neutralizing IgG4 Antibodies Define Natural and Acquired Tolerance in Peanut Allergy

BCR Density Regulates IgE Germinal Center B Cell Survival

Inhibition of Glutamine metabolism is essential in decreasing the hallmarks of Atopic Dermatitis pathogenesis.

IL-33-mediated Mast Cell Function is Female Dominant

The Epstein-Barr virus-induced gene 2-Cholesterol 25-hydroxylase axis is essential for the recruitment of mast cell progenitors.

Germline-encoded recognition underlies development of convergent antibodies in humans

Exocyst complex regulates fungal-mediated IL-33 release and facilitates type 2 immune response

Targeting Pros1 to improve chemotherapy efficacy and immune anti-tumor response

Microbially Induced CD8⁺ Tissue-Resident Memory T Cells Rewire Microglial Function and Suppress Neurogenesis in the Brain

Tmem119+ microglia controls blood-brain barrier disruption through MHC class I restricted antigen presentation in a CNS vascular disease model

ICAM-1 Adhesion Molecules Facilitate Immune Cell Docking at the Cribriform Plate Perineural Microenvironment in Aging

IL-11-induced NLRP3 inflammasome activation mediates pyroptotic cell death in human neurons

Highly dynamic dural sinuses support meningeal immunity

Vessel-Associated Microglia Maintain Vascular Integrity and Prevent Early Hemorrhage in Brain Tumors

Microglial Remodeling of Cerebrovascular Structure and Function during Respiratory Inflammation

Cell cycle-coupled transcriptional network regulates human B cell fate bifurcation

Aging disrupts the affinity threshold for naïve B cell germinal center participation

SLC7A5-mediated glutamine export is required for humoral immunity

Glucose Uptake by Germinal Center B Cells Selectively Sustains Autoimmunity While Sparing Responses to Foreign Antigens

Uncovering a role of aryl hydrocarbon receptor (AhR) in the differentiation dynamics of human B cells

Dynamic nutrient sensing in plasma cells licenses immunoglobulin A secretion

Clinical correlates of maternal antibody interference with oral rotavirus vaccine immunogenicity

Human Spleen Organoids as a Preclinical Platform for Evaluating Vaccine-Induced Antibody Responses

Distinct Inflammatory Programs Underlie the Intramuscular Lipid Nanoparticle Response

In vitro modeling for the in-depth characterization of mRNA vaccines

Sepsis-induced alterations to the microenvironment promotes maladaptive emergency granulopoiesis and susceptibility to Streptococcus pneumoniae

High throughput CRISPR screens reveals novel roles for retroviral elements in proliferation and inflammation in murine macrophages

Neutrophil diversity in the host defense niche

Real-Time Single-Cell Kinetics of Innate Immune Activation

pH-Dependent Innate Immune Circuitry Confers Tolerance to Systemic Inflammation

How do tissues sense proteolytic stress?

A universal CD4 epitope enhances cytotoxic T-cell priming and memory in glioblastoma peptide vaccination

The role of the transcription factor Blimp-1 in T cells in anti-PD1 immunotherapy in non-small cell lung cancer

Mouse EL4 lymphoma strains differentially respond to a loss of BCATc from T cells and αCTLA4 immunotherapy

Extracellular cAMP as a potent immune modulator promotes T cell exhaustion in chronic lymphocytic leukemia

Immunological targeting of the endogenous retroviral protein ERVMER34-1 in carcinomas promotes epitope spread and enhances response to PD-L1 blockade

Identification of a FoxP3-specific small molecule degrader with potent antitumor immunotherapeutic efficacy

Engineered probiotics limit T-cell driven CNS autoimmunity by activating AHR-KLF4-FADS3 signaling in intestinal dendritic cells

Aging-Associated Nrf2 Loss in Microglia Exacerbates Neuroinflammation and Trained Immunity

CD40+ MHC-II+ astrocytes promote Th17 cell-driven CNS autoimmunity

Gamma-Delta T cell-microglia crosstalk drives CD8⁺ T cell infiltration and promotes Alzheimer's-like pathology in APP/PS1 mice

Repeated brain resident memory T cell reactivation induces microglial and T cell remodeling and sustained microglia activation in Alzheimer's disease

Meningeal lymphoid hubs support autoreactive immune responses

Signaling pathways via BAFF receptor/Nav1.7 channel contribute to the activation of monocytes and B cells in patients with Sjögren's disease.

Fractalkine/CX3CL1 Functions as a Transmembrane Receptor to Promote Transendothelial Migration through glycan-dependent condensation

Targeting IL-22 activity to the gut epithelium confers disease benefit without provoking skin inflammation

Anatomic compartmentalization of a cytokine buffer system promotes anti-viral immune defense

CCL20-CCR6 signaling modifies cellular metabolism in CD4 T cells and drives the differentiation of pathogenic Th17 cells

IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection

Wild-Derived Microbiota Protect Against Diet-Induced Obesity via an Immune-Mediated Effect on Brown Adipocytes

Systemic CXCL13 as a possible sex-dependent biomarker to identify neuroinflammation in subclinical food allergies

In Vivo Dynamics of Memory CD8⁺ T Cell Activation Using a Fluorescent Timer Protein of TCR Signaling

Adrenergic Signalling Drives Accumulation of Myeloid-derived Suppressor Cells in the Liver During Stress

Oxysterol-Mediated Modulation of NFB -Linked Systemic Inflammatory Response in a Neonatal Mouse Model of Intestinal Perforation

Double positive (DP) developing thymocytes regulate the development of neuronal cell bodies within the thymus

Kupffer cell identity, phenotype, and function rely on continual hepatic sympathetic nerve output

Functionally divergent resident memory T cells localize to lung and lymph node following influenza infection

MHC-II-restricted neoantigen expression drives tumor infiltration, activation, and maintenance of nonspecific T cells in lung cancer

Tissue-directed maintenance of human B-cell memory after vaccination and infection

Acetyl-CoA generation by Acly distinctly regulates CD4 T cell programming during Plasmodium infection

Quantify the age-related decline of CD8⁺ T cell response to a novel antigen

High-throughput TCR-epitope screening using the Jurkat NFAT Reporter-K562 APC cell system on the Microwell ELISpot Platform

Multi-omics profiling with InTraSeq™ uncovers novel single-cell RNA and Proteomics events in CARTs

Goal-oriented transgenic TCR-T cell design for efficient cancer immunotherapy

Generation and Performance of a DNA Barcode-Based Nuclear Receptor Reporter Library

Development of an in vitro Sjögren's disease tissue chip for mechanistic studies and drug screening

A High-Throughput, Systems-based Neutralizing Antibody Assay Identifies Humoral Features Linked with Compartmentalized Neutralization

Myeloid STAT4 at the Intersection of Sleep Disruption and Hyperlipidemia: A Molecular Link Between Lifestyle Stress and Atherogenesis

Male-Biased Macrophage Signaling and CD8 T Cell Dysfunction Drive Immunosuppression in Pulmonary Fibrosis

Modelling of early-life immunity shaped by contrasting environments

Olfr2 Regulates oxLDL Signaling and Processing, Driving a Pro-inflammatory Foamy Macrophage Phenotype

Immunometabolic Defects in Intestinal CD8⁺ T Cells Disrupt Epithelial Integrity in treated people with HIV

Deletion of RIAM in myeloid cells accelerates tumor growth by macrophage reprogramming

Respiratory viral infections prime accelerated lung cancer growth

MARCKS Drives Immunosuppressive Signaling in Tumor-Associated Macrophages to Promote Lung Cancer Progression

GARP+ Erythroid Regulatory Cells (G-ERCs) define spatially organized immunosuppressive niches that restrain anti-tumor immunity

Olfactory receptor 2+ tumor-associated macrophages activate CD8+ T cells to suppress tumor growth

IgM antibodies and B cells are early responders during acute secondary viral infections and contribute to protection from severe disease

Ptpn22 Restricts Antiviral B cell Response by Modulating BCR Signaling

IgA is necessary and sufficient to protect against norovirus infection

Functional Dynamics of Cytotoxic CD4+ T cells in Acute and Chronic Viral Infections

Immune checkpoint blockade enhances CD4 effector function to control persistent viral infection

Characterising humoral and airway immunity following Respiratory Syncytial Virus infection challenge in older adults

Uncovering cellular programs and regulatory circuits governing cell fate bifurcations using interpretable machine learning

Spatial stochasticity in lymph node microdomains optimizes host protection and enforces self-tolerance

A multilevel logic for antigen interpretation governs tissue-specific T cell responses

The 1000+ mouse project: large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

Evaluating AlphaFold 3 immune complex structure prediction and cryo-EM analysis of broadly neutralizing antibodies towards influenza hemagglutinin

From CRISPR Perturbation Screens Towards Consilient Model-Informed Principles for CAR T-Cell Design

T cell development in early life" (Brian will set the stage on normal immune development

IL-15-Driven NK-like Activation Is Augmented in Senescent CD57+CD8+ Memory T Cells

Multicellular Control of T cell Responses

Sequential interactions with distinct DC subsets direct CD4 T helper cell differentiation

Bystander activation in CD8 memory T cells is an innate program that is standalone from, yet influences TCR and TCR-driven responses

Virtual memory CD8+ T cell behavior is linked to peripheralization in the lymph node.

Immune organ tertiary lymphoid structures (TLSs) as a therapeutic strategy for solid tumors

Loss of the Y chromosome evokes extrinsic extramedullary myelopoiesis via genome-wide epigenetic reprogramming of bladder cancer tumor cells

T6B-mediated inhibition of the miRISC decreases myeloid-derived suppressor cell abundance and enhances survival in a murine ovarian cancer model

Counting to 9: the amazing adventures of the 9th interleukin

Type I Interferon priming in Macrophages is associated with poor responses in Patients with Advanced Prostate Cancer

Defining the Stress-Gut Microbiome Interplay in Anti-Tumor B Cell Response

B cells facilitate immune evasion of metastasizing cancer cells in tumor-draining lymph nodes

Overcoming tumor-intrinsic immunotherapy resistance with hypofractionated radiotherapy

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

Phagocytic CD206+ interstitial macrophages are remodeled after pneumococcal respiratory infection

Lactation-induced granulopoiesis and pulmonary epithelial remodeling enhance maternal antiviral defense

Influenza-driven hematopoietic stem cell reprogramming accelerates atherosclerosis

Steady-state immune surveillance of the nasal mucosa by neutrophils

Eosinophil Activation in the Allergic Lung Limits Pneumococcal Superinfection During Influenza

Helminth trained nerve and airway associated interstitial macrophages are indispensable for mitigating pathology during respiratory viral infection

A novel double-stranded RNA adjuvant markedly amplifies the immunogenicity of nucleoside-modified mRNA-LNP vaccines

The roles of Type I interferon subtypes and signaling in mRNA lipid nanoparticle vaccine-induced CD8 T-cell protective immunity.

IL-15 induces durable resident memory T cell formation and function following genetically attenuated Plasmodium vaccination in mice

Optimizing T Cell Priming Using TLR4/9 Combination Adjuvant For Robust Cell-Mediated Immunity Against Influenza

Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles (BEACON) for Mucosal Vaccination Against Genital Herpes

Type 1 Interferon Restricts mRNA Vaccine Efficacy Through Suppression of Antigen Uptake in Conventional Dendritic Cells

Targeted immunosuppression with a tissue-selective PD-1 agonist prevents rejection of transplanted hearts

ILC3s possess microbiota-inducible acute wound healing potential

Discovery of a novel innate immune cell death pathway, mitoxyperilysis

Resolvins and novel pro-resolving agonists in the resolution of inflammation

Immunometabolic mechanisms of resolution in pulmonary and vascular injury

Multimodal Immune Profiling in Thyroid Eye Disease

Uncovering the immunological determinants of progressive liver disease in X-linked Myotubular Myopathy

Persistent Microbial Peptidoglycan Drives Post-Infectious Autoimmunity in Lyme Disease

Sex-Dependent Immune Dysregulation and Neurodevelopmental Risk in Maternal Substance Use

Inherited C5aR2 deficiency leads to uncontrolled inflammatory T cell responses and autoinflammatory disease

The histone demethylase KDM5C orchestrates VGLL3 and TLR7 crosstalk to drive female-biased autoimmunity

Preliminary immunologic and clinical Phase 1b study outcomes from patients with ROSAH syndrome treated with the first-in-class ALPK1 inhibitor DF-003

Discovery of Exhausted-like Lung Tissue-Resident Memory T Cells as Key Mediators of Protective Immunity - 1

Neutrophil NETosis and cell free DNA suppress T cell responses in glioblastoma